Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Paszkiewicz, Paulina J; Fräßle, Simon P; Srivastava, Shivani; Sommermeyer, Daniel; Hudecek, Michael; Drexler, Ingo; Sadelain, Michel; Liu, Lingfeng; Jensen, Michael C; Riddell, Stanley R; Busch, Dirk H 
Titel:
Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia. 
Abstract:
The adoptive transfer of T cells that have been genetically modified to express a CD19-specific chimeric antigen receptor (CAR) is effective for treating human B cell malignancies. However, the persistence of functional CD19 CAR T cells causes sustained depletion of endogenous CD19+ B cells and hypogammaglobulinemia. Thus, there is a need for a mechanism to ablate transferred T cells after tumor eradication is complete to allow recovery of normal B cells. Previously, we developed a truncated ver...    »
 
Zeitschriftentitel:
J Clin Invest 
Jahr:
2016 
Band / Volume:
126 
Heft / Issue:
11 
Seitenangaben Beitrag:
4262-4272 
Sprache:
eng 
Print-ISSN:
0021-9738 
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene