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Document type:
journal article 
Author(s):
Németh, Tamás; Futosi, Krisztina; Sitaru, Cassian; Ruland, Jürgen; Mócsai, Attila 
Title:
Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo. 
Abstract:
Neutrophils are terminally differentiated cells with limited transcriptional activity. The biological function of their gene expression changes is poorly understood. CARD9 regulates transcription during antifungal immunity but its role in sterile inflammation is unclear. Here we show that neutrophil CARD9 mediates pro-inflammatory chemokine/cytokine but not lipid mediator release during non-infectious inflammation. Genetic deficiency of CARD9 suppresses autoantibody-induced arthritis and dermati...    »
 
Journal title abbreviation:
Nat Commun 
Year:
2016 
Journal volume:
Pages contribution:
11004 
Language:
eng 
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie