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Dokumenttyp:
journal article 
Autor(en):
Németh, Tamás; Futosi, Krisztina; Sitaru, Cassian; Ruland, Jürgen; Mócsai, Attila 
Titel:
Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo. 
Abstract:
Neutrophils are terminally differentiated cells with limited transcriptional activity. The biological function of their gene expression changes is poorly understood. CARD9 regulates transcription during antifungal immunity but its role in sterile inflammation is unclear. Here we show that neutrophil CARD9 mediates pro-inflammatory chemokine/cytokine but not lipid mediator release during non-infectious inflammation. Genetic deficiency of CARD9 suppresses autoantibody-induced arthritis and dermati...    »
 
Zeitschriftentitel:
Nat Commun 
Jahr:
2016 
Band / Volume:
Seitenangaben Beitrag:
11004 
Sprache:
eng 
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie