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Document type:
Zeitschriftenaufsatz 
Author(s):
Verbrugge S, Gehlert S, Stadhouders L, Jacko D, Aussieker T, de Wit G, Offringa C, Schönfelder M, Jaspers R, Wackerhage H 
Title:
The muscle size-regulating enzyme PKM2 limits myofiber growth in vitro and increases in response to resistance exercise in human skeletal muscle 
Abstract:
Nearly 100 years ago, Otto Warburg investigated the metabolism of growing tissues and discovered that tumors reprogram their metabolism. It is poorly understood whether and how hypertrophying muscle, another growing tissue, reprograms its metabolism too. Here, we studied pyruvate kinase muscle (PKM), which can be spliced into two isoforms (PKM1, PKM2). This is of interest, because PKM2 redirects glycolytic flux towards biosynthetic pathways, which might contribute to muscle hypertrophy too. We f...    »
 
Keywords:
Warburg effect; pyruvate kinase; insulin-like growth factor 1; glycolysis; skeletal muscle; hypertrophy; resistance exercise; metabolic reprogramming; cancer 
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit 
Journal title:
International Journal of Molecular Sciences -Biochemistry 
Year:
2020 
Year / month:
2020-09 
Quarter:
3. Quartal 
Month:
Sep 
Reviewed:
ja 
Language:
en 
Fulltext / DOI:
Print-ISSN:
1422-0067 
Impact Factor:
4,556 
Scimago Quartil:
Q1 
Notes:
SCImago Journal &  Country Rank 
Accepted:
23.09.2020 
Semester:
SS 20 
TUM Institution:
Sportbiologie