User: Guest  Login
Document type:
journal article 
Author(s):
Effner, Renate; Hiller, Julia; Eyerich, Stefanie; Traidl-Hoffmann, Claudia; Brockow, Knut; Triggiani, Massimo; Behrendt, Heidrun; Schmidt-Weber, Carsten B; Buters, Jeroen T M 
Title:
Cytochrome P450s in human immune cells regulate IL-22 and c-Kit via an AHR feedback loop. 
Abstract:
The mechanisms how environmental compounds influence the human immune system are unknown. The environmentally sensitive transcription factor aryl hydrocarbon receptor (AHR) has immune-modulating functions and responds to small molecules. Cytochrome P4501 enzymes (CYP1) act downstream of the AHR and metabolize small molecules. However, it is currently unknown whether CYP1 activity is relevant for immune modulation. We studied the interdependence of CYP1 and AHR in human primary immune cells using...    »
 
Journal title abbreviation:
Sci Rep 
Year:
2017 
Journal volume:
Pages contribution:
44005 
Language:
eng 
Fulltext / DOI:
TUM Institution:
Institut für Molekulare Allergologie; Klinik und Poliklinik für Dermatologie und Allergologie