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Dokumenttyp:
journal article 
Autor(en):
Heink, Sylvia; Yogev, Nir; Garbers, Christoph; Herwerth, Marina; Aly, Lilian; Gasperi, Christiane; Husterer, Veronika; Croxford, Andrew L; Möller-Hackbarth, Katja; Bartsch, Harald S; Sotlar, Karl; Krebs, Stefan; Regen, Tommy; Blum, Helmut; Hemmer, Bernhard; Misgeld, Thomas; Wunderlich, Thomas F; Hidalgo, Juan; Oukka, Mohamed; Rose-John, Stefan; Schmidt-Supprian, Marc; Waisman, Ari; Korn, Thomas 
Titel:
Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. 
Abstract:
The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the TH17 subset of helper T cells remain unclear. Here we used a novel strategy for the conditional deletion of distinct IL-6-producing cell types to show that dendritic cells (DCs) positive for the signaling regulator Sirp? were essential for the generation of pathogenic TH17 cells. Using their IL-6 receptor ?-chain (IL-6R?), Sirp?(+) DCs trans-presented IL-6 to T cells during the process of cognate interactio...    »
 
Zeitschriftentitel:
Nat Immunol 
Jahr:
2017 
Band / Volume:
18 
Heft / Issue:
Seitenangaben Beitrag:
74-85 
Sprache:
eng 
Print-ISSN:
1529-2908 
TUM Einrichtung:
Lehrstuhl für Molekulare Neuroimmunologie; Neurologische Klinik und Poliklinik; III. Medizinische Klinik und Poliklinik