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Dokumenttyp:
journal article 
Autor(en):
Zimmer, Lisa; Goldinger, Simone M; Hofmann, Lars; Loquai, Carmen; Ugurel, Selma; Thomas, Ioannis; Schmidgen, Maria I; Gutzmer, Ralf; Utikal, Jochen S; Göppner, Daniela; Hassel, Jessica C; Meier, Friedegund; Tietze, Julia K; Forschner, Andrea; Weishaupt, Carsten; Leverkus, Martin; Wahl, Renate; Dietrich, Ursula; Garbe, Claus; Kirchberger, Michael C; Eigentler, Thomas; Berking, Carola; Gesierich, Anja; Krackhardt, Angela M; Schadendorf, Dirk; Schuler, Gerold; Dummer, Reinhard; Heinzerling, Lucie M 
Titel:
Neurological, respiratory, musculoskeletal, cardiac and ocular side-effects of anti-PD-1 therapy. 
Abstract:
Anti-programmed cell death 1 (PD-1) antibodies represent an effective treatment option for metastatic melanoma and other cancer entities. They act via blockade of the PD-1 receptor, an inhibitor of the T-cell effector mechanisms that limit immune responses against tumours. As reported for ipilimumab, the anti-PD-1 antibodies pembrolizumab and nivolumab can induce immune-related adverse events (irAEs). These side-effects can involve skin, gastrointestinal tract, liver, the endocrine system and ot...    »
 
Zeitschriftentitel:
Eur J Cancer 
Jahr:
2016 
Band / Volume:
60 
Seitenangaben Beitrag:
210-25 
Sprache:
eng 
Print-ISSN:
0959-8049 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik