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Dokumenttyp:
journal article 
Autor(en):
Ruf, Franziska; Schreck, Christina; Wagner, Alina; Grziwok, Sandra; Pagel, Charlotta; Romero, Sandra; Kieslinger, Matthias; Shimono, Akihiko; Peschel, Christian; Götze, Katharina S; Istvanffy, Rouzanna; Oostendorp, Robert A J 
Titel:
Loss of Sfrp2 in the Niche Amplifies Stress-Induced Cellular Responses, and Impairs the In Vivo Regeneration of the Hematopoietic Stem Cell Pool. 
Abstract:
Sfrp2 is overexpressed in stromal cells which maintain hematopoietic stem cells (HSCs) during in vitro culture. We here showed, that coculture of hematopoetic cells with stromal cells with reduced expression of Sfrp2 increases the number lineage-negative Kit(+) Sca-1(+) (LSK) and progenitor cells in vitro. The LSK cells from these cocultures showed activation of canonical Wnt signaling, higher levels of Ki-67, BrdU incorporation, and the number of ?H2A.X positive foci. Total repopulating activit...    »
 
Zeitschriftentitel:
Stem Cells 
Jahr:
2016 
Band / Volume:
34 
Heft / Issue:
Seitenangaben Beitrag:
2381-92 
Sprache:
eng 
Print-ISSN:
1066-5099 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik