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Dokumenttyp:
journal article 
Autor(en):
Togliatto, Gabriele; Trombetta, Antonella; Dentelli, Patrizia; Cotogni, Paolo; Rosso, Arturo; Tschöp, Matthias H; Granata, Riccarda; Ghigo, Ezio; Brizzi, Maria F 
Titel:
Unacylated ghrelin promotes skeletal muscle regeneration following hindlimb ischemia via SOD-2-mediated miR-221/222 expression. 
Abstract:
Surgical treatment of peripheral artery disease, even if successful, does not prevent reoccurrence. Under these conditions, increased oxidative stress is a crucial determinant of tissue damage. Given its reported antioxidant effects, we investigated the potential of unacylated-ghrelin (UnAG) to reduce ischemia-induced tissue damage in a mouse model of peripheral artery disease.We show that UnAG but not acylated ghrelin (AG) induces skeletal muscle regeneration in response to ischemia via canonic...    »
 
Zeitschriftentitel:
J Am Heart Assoc 
Jahr:
2013 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
e000376 
Sprache:
eng 
TUM Einrichtung:
Fakultät für Medizin (zentral angehängte Professuren und Einrichtungen: Profs. Tschöp, Berberat; TUMCells, ZPF, MSZ)