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Dokumenttyp:
journal article 
Autor(en):
Wieland, Elfriede; Rodriguez-Vita, Juan; Liebler, Sven S; Mogler, Carolin; Moll, Iris; Herberich, Stefanie E; Espinet, Elisa; Herpel, Esther; Menuchin, Amitai; Chang-Claude, Jenny; Hoffmeister, Michael; Gebhardt, Christoffer; Brenner, Hermann; Trumpp, Andreas; Siebel, Christian W; Hecker, Markus; Utikal, Jochen; Sprinzak, David; Fischer, Andreas 
Titel:
Endothelial Notch1 Activity Facilitates Metastasis. 
Abstract:
Endothelial cells (ECs) provide angiocrine factors orchestrating tumor progression. Here, we show that activated Notch1 receptors (N1ICD) are frequently observed in ECs of human carcinomas and melanoma, and in ECs of the pre-metastatic niche in mice. EC N1ICD expression in melanoma correlated with shorter progression-free survival. Sustained N1ICD activity induced EC senescence, expression of chemokines and the adhesion molecule VCAM1. This promoted neutrophil infiltration, tumor cell (TC) adhes...    »
 
Zeitschriftentitel:
Cancer Cell 
Jahr:
2017 
Band / Volume:
31 
Heft / Issue:
Seitenangaben Beitrag:
355-367 
Sprache:
eng 
Print-ISSN:
1535-6108 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie