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Dokumenttyp:
journal article 
Autor(en):
Bruch, Julius; Xu, Hong; Rösler, Thomas W; De Andrade, Anderson; Kuhn, Peer-Hendrik; Lichtenthaler, Stefan F; Arzberger, Thomas; Winklhofer, Konstanze F; Müller, Ulrich; Höglinger, Günter U 
Titel:
PERK activation mitigates tau pathology in vitro and in vivo. 
Abstract:
The RNA-like endoplasmic reticulum kinase (PERK) is genetically associated with the tauopathy progressive supranuclear palsy (PSP). To elucidate the functional mechanisms underlying this association, we explored PERK activity in brains of PSP patients and its function in three tauopathy models (cultured human neurons overexpressing 4-repeat wild-type tau or treated with the environmental neurotoxin annonacin, and P301S tau transgenic mice). In vitro, treatment with a pharmacological PERK activat...    »
 
Zeitschriftentitel:
EMBO Mol Med 
Jahr:
2017 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
371-384 
Sprache:
eng 
Print-ISSN:
1757-4676 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie