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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Gande, Santosh L.; Saxena, Krishna; Sreeramulu, Sridhar; Linhard, Verena; Kudlinzki, Denis; Heinzlmeir, Stephanie; Reichert, Andreas J.; Skerra, Arne; Kuster, Bernhard; Schwalbe, Harald 
Titel:
Expression and Purification of EPHA2 Tyrosine Kinase Domain for Crystallographic and NMR Studies 
Abstract:
The receptor tyrosine kinase EPHA2 is overexpressed in several cancer entities (breast, head and neck, non-small cell lung cancer). Small molecule-based inhibition of the activity of the EPHA2 kinase domain (KD) has been seen as an important strategy for achieving therapeutic intervention. However, obtaining structural information by protein crystallography or by NMR spectroscopy aiding drug discovery, has been severely hampered due to the lack of pure and homogeneous protein. Here different fra...    »
 
Stichworte:
BayBioMS 
Zeitschriftentitel:
ChemBioChem 
Jahr:
2016 
Band / Volume:
17 
Heft / Issue:
23 
Seitenangaben Beitrag:
2257-2263 
Verlag / Institution:
Wiley-Blackwell 
E-ISSN:
1439-4227 
Publikationsdatum:
09.11.2016