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Dokumenttyp:
Zeitschriftenaufsatz 
Autor(en):
Yu, Peng; Hahne, Hannes; Wilhelm, Mathias; Kuster, Bernhard 
Titel:
Ethylene glycol improves electrospray ionization efficiency in bottom-up proteomics 
Abstract:
Liquid chromatography coupled online to nano-electrospray ionization (nESI) tandem mass spectrometry is the analytical workhorse in the field of proteome research. Dimethyl sulfoxide (DMSO) was recently shown to improve nESI efficiency by a factor of three to ten thus improving the sensitivity and coverage of proteomic experiments. However, relatively few investigations into which solvent additives promote nESI response have been performed at a proteomic scale. Here, we systematically evaluated...    »
 
Stichworte:
BayBioMS 
Zeitschriftentitel:
Analytical and Bioanalytical Chemistry 
Jahr:
2016 
Band / Volume:
409 
Heft / Issue:
Seitenangaben Beitrag:
1049-1057 
Verlag / Institution:
Springer Nature 
E-ISSN:
1618-26421618-2650 
Publikationsdatum:
20.10.2016