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Dokumenttyp:
journal article 
Autor(en):
Shevtsov, Maxim; Multhoff, Gabriele 
Titel:
Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer. 
Abstract:
Intracellular residing heat shock proteins (HSPs) with a molecular weight of approximately 70 and 90 kDa function as molecular chaperones that assist folding/unfolding and transport of proteins across membranes and prevent protein aggregation after environmental stress. In contrast to normal cells, tumor cells have higher cytosolic heat shock protein 70 and Hsp90 levels, which contribute to tumor cell propagation, metastasis, and protection against apoptosis. In addition to their intracellular c...    »
 
Zeitschriftentitel:
Front Immunol 
Jahr:
2016 
Band / Volume:
Seitenangaben Beitrag:
171 
Sprache:
eng 
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie