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Dokumenttyp:
journal article 
Autor(en):
Kinzel, Linda; Ernst, Anne; Orth, Michael; Albrecht, Valerie; Hennel, Roman; Brix, Nikko; Frey, Benjamin; Gaipl, Udo S; Zuchtriegel, Gabriele; Reichel, Christoph A; Blutke, Andreas; Schilling, Daniela; Multhoff, Gabriele; Li, Minglun; Niyazi, Maximilian; Friedl, Anna A; Winssinger, Nicolas; Belka, Claus; Lauber, Kirsten 
Titel:
A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer. 
Abstract:
The chaperone heat shock protein 90 (HSP90) crucially supports the maturation, folding, and stability of a variety of client proteins which are of pivotal importance for the survival and proliferation of cancer cells. Consequently, targeting of HSP90 has emerged as an attractive strategy of anti-cancer therapy, and it appears to be particularly effective in the context of molecular sensitization towards radiotherapy as has been proven in preclinical models of different cancer entities. However,...    »
 
Zeitschriftentitel:
Oncotarget 
Jahr:
2016 
Band / Volume:
Heft / Issue:
28 
Seitenangaben Beitrag:
43199-43219 
Sprache:
eng 
TUM Einrichtung:
Klinik und Poliklinik für RadioOnkologie und Strahlentherapie