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Dokumenttyp:
journal article 
Autor(en):
Antel, J; Ban, M; Baranzini, S; Barcellos, L; Barizzone, N; Beecham, A; Berge, T; Bernardinelli, L; Booth, D; Bos, S; Buck, D; Butkiewicz, M; Celius, EG; Comabella, M; Compston, A; Dedham, K; Cotsapas, C; Alfonso, SD; De Jager, P; Dubois, B; Duquette, P; Fontaine, B; Gasperi, C; Gil, E; Goris, A; Gourraud, PA; Graetz, C; Gyllenberg, A; Hadjigeorgiou, G; Hafler, D; Hribko, D; Haines, J; Harbo, H; Hauser, S; Warto, S; Hawkins, C; Hemmer, B; Henry, R; Hintzen, R; Horakova, D; Ivinson, A; Howard, M;...    »
 
Titel:
NR1H3 p.Arg415Gln Is Not Associated to Multiple Sclerosis Risk 
Abstract:
A recent study by Wang et al. (2016a) claims that the low-frequency variant NR1H3 p.Arg415Gln is sufficient to cause multiple sclerosis in certain individuals and determines a patient's likelihood of primary progressive disease. We sought to replicate this finding in the International MS Genetics Consortium(IMSGC) patient collection, which is 13-fold larger than the collection of Wang et al. (2016a), but we find no evidence that this variant is associated with either MS or disease subtype. Wang...    »
 
Zeitschriftentitel:
Neuron 
Jahr:
2016 
Band / Volume:
92 
Heft / Issue:
Seitenangaben Beitrag:
333-335 
Sprache:
eng 
Print-ISSN:
0896-6273 
TUM Einrichtung:
Neurologische Klinik und Poliklinik