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Dokumenttyp:
journal article 
Autor(en):
Konzack, Anja; Jakupovic, Mirza; Kubaichuk, Kateryna; Görlach, Agnes; Dombrowski, Frank; Miinalainen, Ilkka; Sormunen, Raija; Kietzmann, Thomas 
Titel:
Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis. 
Abstract:
One of the cancer hallmarks is mitochondrial dysfunction associated with oxidative stress. Among the first line of defense against oxidative stress is the dismutation of superoxide radicals, which in the mitochondria is carried out by manganese superoxide dismutase (MnSOD). Accordingly, carcinogenesis would be associated with a dysregulation in MnSOD expression. However, the association studies available so far are conflicting, and no direct proof concerning the role of MnSOD as a tumor promoter...    »
 
Zeitschriftentitel:
Antioxid Redox Signal 
Jahr:
2015 
Band / Volume:
23 
Heft / Issue:
14 
Seitenangaben Beitrag:
1059-75 
Sprache:
eng 
Print-ISSN:
1523-0864 
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler