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Dokumenttyp:
journal article 
Autor(en):
Chalupsky, Karel; Kra?un, Damir; Kanchev, Ivan; Bertram, Katharina; Görlach, Agnes 
Titel:
Folic Acid Promotes Recycling of Tetrahydrobiopterin and Protects Against Hypoxia-Induced Pulmonary Hypertension by Recoupling Endothelial Nitric Oxide Synthase. 
Abstract:
Nitric oxide (NO) derived from endothelial NO synthase (eNOS) has been implicated in the adaptive response to hypoxia. An imbalance between 5,6,7,8-tetrahydrobiopterin (BH4) and 7,8-dihydrobiopterin (BH2) can result in eNOS uncoupling and the generation of superoxide instead of NO. Dihydrofolate reductase (DHFR) can recycle BH2 to BH4, leading to eNOS recoupling. However, the role of DHFR and eNOS recoupling in the response to hypoxia is not well understood. We hypothesized that increasing the c...    »
 
Zeitschriftentitel:
Antioxid Redox Signal 
Jahr:
2015 
Band / Volume:
23 
Heft / Issue:
14 
Seitenangaben Beitrag:
1076-91 
Sprache:
eng 
Print-ISSN:
1523-0864 
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler