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Dokumenttyp:
journal article 
Autor(en):
Zissler, U M; Chaker, A M; Effner, R; Ulrich, M; Guerth, F; Piontek, G; Dietz, K; Regn, M; Knapp, B; Theis, F J; Heine, H; Suttner, K; Schmidt-Weber, C B 
Titel:
Interleukin-4 and interferon-? orchestrate an epithelial polarization in the airways. 
Abstract:
Interferon-? (IFN-?) and interleukin-4 (IL-4) are key effector cytokines for the differentiation of T helper type 1 and 2 (Th1 and Th2) cells. Both cytokines induce fate-decisive transcription factors such as GATA3 and TBX21 that antagonize the polarized development of opposite phenotypes by direct regulation of each other's expression along with many other target genes. Although it is well established that mesenchymal cells directly respond to Th1 and Th2 cytokines, the nature of antagonistic d...    »
 
Zeitschriftentitel:
Mucosal Immunol 
Jahr:
2016 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
917-26 
Sprache:
eng 
Print-ISSN:
1933-0219 
TUM Einrichtung:
Institut für Molekulare Allergologie und Umweltforschung