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Dokumenttyp:
journal article 
Autor(en):
Kong, Bo; Bruns, Philipp; Behler, Nora A; Chang, Ligong; Schlitter, Anna Melissa; Cao, Jing; Gewies, Andreas; Ruland, Jürgen; Fritzsche, Sina; Valkovskaya, Nataliya; Jian, Ziying; Regel, Ivonne; Raulefs, Susanne; Irmler, Martin; Beckers, Johannes; Friess, Helmut; Erkan, Mert; Mueller, Nikola S; Roth, Susanne; Hackert, Thilo; Esposito, Irene; Theis, Fabian J; Kleeff, Jörg; Michalski, Christoph W 
Titel:
Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy. 
Abstract:
The initial steps of pancreatic regeneration versus carcinogenesis are insufficiently understood. Although a combination of oncogenic Kras and inflammation has been shown to induce malignancy, molecular networks of early carcinogenesis remain poorly defined.We compared early events during inflammation, regeneration and carcinogenesis on histological and transcriptional levels with a high temporal resolution using a well-established mouse model of pancreatitis and of inflammation-accelerated Kras...    »
 
Zeitschriftentitel:
Gut 
Jahr:
2016 
Sprache:
eng 
Print-ISSN:
0017-5749 
TUM Einrichtung:
Chirurgiesche Klinik und Poliklinik; Institut für Allgemeine Pathologie und pathologische Anatomie; Institut für Klinische Chemie und Pathobiochemie