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Dokumenttyp:
journal article 
Autor(en):
Pfarr, Nicole; Penzel, Roland; Endris, Volker; Lier, Clemens; Flechtenmacher, Christa; Volckmar, Anna-Lena; Kirchner, Martina; Budczies, Jan; Leichsenring, Jonas; Herpel, Esther; Noske, Aurelia; Weichert, Wilko; Schneeweiss, Andreas; Schirmacher, Peter; Sinn, Hans-Peter; Stenzinger, Albrecht 
Titel:
Targeted next-generation sequencing enables reliable detection of HER2 (ERBB2) status in breast cancer and provides ancillary information of clinical relevance. 
Abstract:
HER2-positive breast cancers are a heterogeneous group of tumors, which share amplification and overexpression of HER2. In routine diagnostics, the HER2 (ERBB2) status is currently assessed by immunohistochemistry (IHC) and in situ hybridization (ISH). Data on targeted next-generation sequencing (NGS) approaches that could be used to determine the HER2 status are sparse. Employing two breast cancer-related gene panels, we performed targeted NGS of 41 FFPE breast cancers for which full pathologic...    »
 
Zeitschriftentitel:
Genes Chromosomes Cancer 
Jahr:
2017 
Band / Volume:
56 
Heft / Issue:
Seitenangaben Beitrag:
255-265 
Sprache:
eng 
Print-ISSN:
1045-2257 
TUM Einrichtung:
Institut für Allgemeine Pathologie und pathologische Anatomie