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Dokumenttyp:
journal article 
Autor(en):
Höckendorf, Ulrike; Yabal, Monica; Herold, Tobias; Munkhbaatar, Enkhtsetseg; Rott, Stephanie; Jilg, Stefanie; Kauschinger, Johanna; Magnani, Giovanni; Reisinger, Florian; Heuser, Michael; Kreipe, Hans; Sotlar, Karl; Engleitner, Thomas; Rad, Roland; Weichert, Wilko; Peschel, Christian; Ruland, Jürgen; Heikenwalder, Mathias; Spiekermann, Karsten; Slotta-Huspenina, Julia; Groß, Olaf; Jost, Philipp J 
Titel:
RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells. 
Abstract:
Since acute myeloid leukemia (AML) is characterized by the blockade of hematopoietic differentiation and cell death, we interrogated RIPK3 signaling in AML development. Genetic loss of Ripk3 converted murine FLT3-ITD-driven myeloproliferation into an overt AML by enhancing the accumulation of leukemia-initiating cells (LIC). Failed inflammasome activation and cell death mediated by tumor necrosis factor receptor caused this accumulation of LIC exemplified by accelerated leukemia onset in Il1r1(-...    »
 
Zeitschriftentitel:
Cancer Cell 
Jahr:
2016 
Band / Volume:
30 
Heft / Issue:
Seitenangaben Beitrag:
75-91 
Sprache:
eng 
Print-ISSN:
1535-6108 
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik; II. Medizinische Klinik und Poliklinik; Institut für Allgemeine Pathologie und pathologische Anatomie