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Dokumenttyp:
journal article 
Autor(en):
IL6R Genetics Consortium Emerging Risk Factors Collaboration; Sarwar, N; Butterworth, AS; Freitag, DF; Gregson, J; Willeit, P; Gorman, DN; Gao, P; Saleheen, D; Rendon, A; Nelson, CP; Braund, PS; Hall, AS; Chasman, DI; Tybjærg-Hansen, A; Chambers, JC; Benjamin, EJ; Franks, PW; Clarke, R; Wilde, AA; Trip, MD; Steri, M; Witteman, JC; Qi, L; van der Schoot, CE; de Faire, U; Erdmann, J; Stringham, HM; Koenig, W; Rader, DJ; Melzer, D; Reich, D; Psaty, BM; Kleber, ME; Panagiotakos, DB; Willeit, J; Wenn...    »
 
Titel:
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. 
Abstract:
Persistent inflammation has been proposed to contribute to various stages in the pathogenesis of cardiovascular disease. Interleukin-6 receptor (IL6R) signalling propagates downstream inflammation cascades. To assess whether this pathway is causally relevant to coronary heart disease, we studied a functional genetic variant known to affect IL6R signalling.In a collaborative meta-analysis, we studied Asp358Ala (rs2228145) in IL6R in relation to a panel of conventional risk factors and inflammatio...    »
 
Zeitschriftentitel:
Lancet 
Jahr:
2012 
Band / Volume:
379 
Heft / Issue:
9822 
Seitenangaben Beitrag:
1205-13 
Sprache:
eng 
Print-ISSN:
0140-6736 
TUM Einrichtung:
r Herz- und Kreislauferkrankungen