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Dokumenttyp:
journal article 
Autor(en):
Beyerle, A; Braun, A; Merkel, O; Koch, F; Kissel, T; Stoeger, T 
Titel:
Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice. 
Abstract:
Pulmonary siRNA delivery offers a new way to treat various lung diseases. Poly(ethylene imines) (PEIs) are promising cationic nanocarriers and various modifications are still under investigations to improve their cytotoxicity and efficacy for siRNA delivery. In this study, we analyzed two different types of PEI-based nanocomplexes in mice after intratracheal administration regarding their toxicity and efficacy in the lungs. Ubiquitously enhanced green fluorescent protein (EGFP) expressing transg...    »
 
Zeitschriftentitel:
J Control Release 
Jahr:
2011 
Band / Volume:
151 
Heft / Issue:
Seitenangaben Beitrag:
51-6 
Sprache:
eng 
Print-ISSN:
0168-3659 
TUM Einrichtung:
r Molekulare Allergologie und Umweltforschung