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Dokumenttyp:
journal article 
Autor(en):
Heidel, SM; MacWilliams, PS; Baird, WM; Dashwood, WM; Buters, JT; Gonzalez, FJ; Larsen, MC; Czuprynski, CJ; Jefcoate, CR 
Titel:
Cytochrome P4501B1 mediates induction of bone marrow cytotoxicity and preleukemia cells in mice treated with 7,12-dimethylbenz[a]anthracene. 
Abstract:
Humans are exposed to polycyclic aromatic hydrocarbons (PAHs) through many environmental pollutants, especially cigarette smoke. These chemicals cause a variety of tumors and immunotoxic effects, as a consequence of bioactivation by P-450 cytochromes to dihydrodiol epoxides. The recently identified cytochrome P4501B1 (CYP1B1) bioactivates PAHs but is also a physiological regulator, as evidenced by linkage of CYP1B1 deficiency to congenital human glaucoma. This investigation demonstrates that CYP...    »
 
Zeitschriftentitel:
Cancer Res 
Jahr:
2000 
Band / Volume:
60 
Heft / Issue:
13 
Seitenangaben Beitrag:
3454-60 
Sprache:
eng 
Print-ISSN:
0008-5472 
TUM Einrichtung:
r Molekulare Allergologie und Umweltforschung