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Document type:
journal article 
Author(s):
Buters, JT; Sakai, S; Richter, T; Pineau, T; Alexander, DL; Savas, U; Doehmer, J; Ward, JM; Jefcoate, CR; Gonzalez, FJ 
Title:
Cytochrome P450 CYP1B1 determines susceptibility to 7, 12-dimethylbenz[a]anthracene-induced lymphomas. 
Abstract:
CYP1B1-null mice, created by targeted gene disruption in embryonic stem cells, were born at the expected frequency from heterozygous matings with no observable phenotype, thus establishing that CYP1B1 is not required for mouse development. CYP1B1 was not detectable in cultured embryonic fibroblast (EF) or in different tissues, such as lung, of the CYP1B1-null mouse treated with the aryl hydrocarbon receptor agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin whereas the equivalent wild-type EF cells exp...    »
 
Journal title abbreviation:
Proc Natl Acad Sci U S A 
Year:
1999 
Journal volume:
96 
Journal issue:
Pages contribution:
1977-82 
Language:
eng 
Print-ISSN:
0027-8424 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung