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Document type:
journal article 
Author(s):
Bourdi, M; Chen, W; Peter, RM; Martin, JL; Buters, JT; Nelson, SD; Pohl, LR 
Title:
Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. 
Abstract:
Autoantibodies against specific human cytochrome P450s have been found in the sera of patients suffering from a variety of diseases, including those caused by drugs. In the cases of tienilic acid- and dihydralazine-induced hepatitis, patients have serum autoantibodies directed against cytochromes P450 2C9 and P450 1A2, respectively. In the present study, we have found that 25 of 56 (45%) patients diagnosed with halothane hepatitis have autoantibodies that react with human cytochrome P450 2E1 tha...    »
 
Journal title abbreviation:
Chem Res Toxicol 
Year:
1996 
Journal volume:
Journal issue:
Pages contribution:
1159-66 
Language:
eng 
Print-ISSN:
0893-228X 
TUM Institution:
Institut für Molekulare Allergologie und Umweltforschung