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Dokumenttyp:
journal article 
Autor(en):
Sousa, Mda G; Reid, DM; Schweighoffer, E; Tybulewicz, V; Ruland, J; Langhorne, J; Yamasaki, S; Taylor, PR; Almeida, SR; Brown, GD 
Titel:
Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin. 
Abstract:
Chromoblastomycosis is a chronic skin infection caused by the fungus Fonsecaea pedrosoi. Exploring the reasons underlying the chronic nature of F. pedrosoi infection in a murine model of chromoblastomycosis, we find that chronicity develops due to a lack of pattern recognition receptor (PRR) costimulation. F. pedrosoi was recognized primarily by C-type lectin receptors (CLRs), but not by Toll-like receptors (TLRs), which resulted in the defective induction of proinflammatory cytokines. Inflammat...    »
 
Zeitschriftentitel:
Cell Host Microbe 
Jahr:
2011 
Band / Volume:
Heft / Issue:
Seitenangaben Beitrag:
436-43 
Sprache:
eng 
Print-ISSN:
1931-3128 
TUM Einrichtung:
r Molekulare Immunologie