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Document type:
journal article 
Author(s):
Mankan, AK; Greten, FR 
Title:
Inhibiting signal transducer and activator of transcription 3: rationality and rationale design of inhibitors. 
Abstract:
INTRODUCTION: Signal transducer and activator of transcription 3 (STAT3) controls a key signaling pathway in the development of many malignant diseases. Several genetic studies have proven its central role in the regulation of apoptosis, proliferation, angiogenesis and immune responses making it an attractive target for cancer therapy. AREAS COVERED: This article addresses the role of STAT3 in immune response modulation and highlights the contribution of STAT3 in inflammation-mediated tumorigene...    »
 
Journal title abbreviation:
Expert Opin Investig Drugs 
Year:
2011 
Journal volume:
20 
Journal issue:
Pages contribution:
1263-75 
Language:
eng 
Print-ISSN:
1354-3784 
TUM Institution:
Institut für Molekulare Immunologie