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Document type:
journal article 
Author(s):
Vogel, TU; Reynolds, MR; Fuller, DH; Vielhuber, K; Shipley, T; Fuller, JT; Kunstman, KJ; Sutter, G; Marthas, ML; Erfle, V; Wolinsky, SM; Wang, C; Allison, DB; Rud, EW; Wilson, N; Montefiori, D; Altman, JD; Watkins, DI 
Title:
Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239. 
Abstract:
Given the current difficulties generating vaccine-induced neutralizing antibodies to human immunodeficiency virus (HIV), the focus of the vaccine community has shifted toward creating cytotoxic-T-lymphocyte (CTL)-based vaccines. Recent reports of CTL-based vaccine trials in macaques challenged with simian/human immunodeficiency virus SHIV-89.6P have supported the notion that such vaccines can ameliorate the course of disease. However, almost all of these studies included Env as an immunogen and...    »
 
Journal title abbreviation:
J Virol 
Year:
2003 
Journal volume:
77 
Journal issue:
24 
Pages contribution:
13348-60 
Language:
eng 
Print-ISSN:
0022-538X 
TUM Institution:
Institut für Virologie