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Dokumenttyp:
journal article 
Autor(en):
Gilch, S; Wopfner, F; Renner-Müller, I; Kremmer, E; Bauer, C; Wolf, E; Brem, G; Groschup, MH; Schätzl, HM 
Titel:
Polyclonal anti-PrP auto-antibodies induced with dimeric PrP interfere efficiently with PrPSc propagation in prion-infected cells. 
Abstract:
Prion diseases are neurodegenerative infectious disorders for which no prophylactic regimens are known. In order to induce antibodies/auto-antibodies directed against surface-located PrP(c), we used a covalently linked dimer of mouse prion protein expressed recombinantly in Escherichia coli. Employing dimeric PrP as an immunogen we were able to effectively overcome autotolerance against murine PrP in PrP wild-type mice without inducing obvious side effects. Treatment of prion-infected mouse cell...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2003 
Band / Volume:
278 
Heft / Issue:
20 
Seitenangaben Beitrag:
18524-31 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
r Virologie