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Dokumenttyp:
journal article 
Autor(en):
Cordes, N; Seidler, J; Durzok, R; Geinitz, H; Brakebusch, C 
Titel:
beta1-integrin-mediated signaling essentially contributes to cell survival after radiation-induced genotoxic injury. 
Abstract:
Integrin-mediated adhesion to extracellular matrix proteins confers resistance to radiation- or drug-induced genotoxic injury. To analyse the underlying mechanisms specific for beta1-integrins, wild-type beta1A-integrin-expressing GD25beta1A cells were compared to GD25beta1B cells, which express signaling-incompetent beta1B variants. Cells grown on fibronectin, collagen-III, beta1-integrin-IgG or poly-l-lysine were exposed to 0-6 Gy X-rays in presence or depletion of growth factors and phosphati...    »
 
Zeitschriftentitel:
Oncogene 
Jahr:
2006 
Band / Volume:
25 
Heft / Issue:
Seitenangaben Beitrag:
1378-90 
Sprache:
eng 
Print-ISSN:
0950-9232 
TUM Einrichtung:
r RadioOnkologie und Strahlentherapie