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Dokumenttyp:
journal article 
Autor(en):
Philbrook, C; Fritz, E; Weiher, H 
Titel:
Expressional and functional studies of Wolframin, the gene function deficient in Wolfram syndrome, in mice and patient cells. 
Abstract:
Wolfram Syndrome is an autosomal recessive degenerative disorder of the neuroendocrine system. Diabetes mellitus is its lead symptom. Patients show mutations in the wolframin (WFS1) gene coding for a hydrophobic transmembrane protein of 890 amino acids. This protein was preliminarily localised in the endoplasmatic reticulum (ER) in cells of mice and rats. Mice lacking the WFS1 gene display degeneration of pancreatic beta-cells following induction of ER stress. We here used antibodies against sub...    »
 
Zeitschriftentitel:
Exp Gerontol 
Jahr:
2005 
Band / Volume:
40 
Heft / Issue:
8-9 
Seitenangaben Beitrag:
671-8 
Sprache:
eng 
Print-ISSN:
0531-5565 
TUM Einrichtung:
r RadioOnkologie und Strahlentherapie