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Dokumenttyp:
journal article 
Autor(en):
Wegener, JW; Schulla, V; Koller, A; Klugbauer, N; Feil, R; Hofmann, F 
Titel:
Control of intestinal motility by the Ca(v)1.2 L-type calcium channel in mice. 
Abstract:
The Ca(v)1.2 L-type Ca2+ channel is the dominant voltage-activated Ca2+ channel in heart and smooth muscle. The functional significance of this channel was studied in intestinal smooth muscle from mice carrying a smooth muscle-specific, conditional inactivation of the Ca(v)1.2 gene (Ca(v)1.2SMACKO mice). Inactivation was complete within 4 wk after tamoxifen treatment and confirmed by RT-PCR, Western blot and functional analysis. Ca(v)1.2SMACKO mice show reduced feces excretion, absence of rhythm...    »
 
Zeitschriftentitel:
FASEB J 
Jahr:
2006 
Band / Volume:
20 
Heft / Issue:
Seitenangaben Beitrag:
1260-2 
Sprache:
eng 
Print-ISSN:
0892-6638 
TUM Einrichtung:
r Pharmakologie und Toxikologie