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Document type:
journal article 
Author(s):
Werner, CG; Godfrey, V; Arnold, RR; Featherstone, GL; Bender, D; Schlossmann, J; Schiemann, M; Hofmann, F; Pryzwansky, KB 
Title:
Neutrophil dysfunction in guanosine 3',5'-cyclic monophosphate-dependent protein kinase I-deficient mice. 
Abstract:
The regulation of neutrophil functions by Type I cGMP-dependent protein kinase (cGKI) was investigated in wild-type (WT) and cGKI-deficient (cGKI-/-) mice. We demonstrate that murine neutrophils expressed cGKIalpha. Similar to the regulation of Ca2+ by cGKI in other cells, there was a cGMP-dependent decrease in Ca2+ transients in response to C5a in WT, but not cGKI-/- bone marrow neutrophils. In vitro chemotaxis of bone marrow neutrophils to C5a or IL-8 was significantly greater in cGKI-/- than...    »
 
Journal title abbreviation:
J Immunol 
Year:
2005 
Journal volume:
175 
Journal issue:
Pages contribution:
1919-29 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Pharmakologie und Toxikologie