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Document type:
journal article 
Author(s):
Brill, J; Klocke, R; Paul, D; Boison, D; Gouder, N; Klugbauer, N; Hofmann, F; Becker, CM; Becker, K 
Title:
entla, a novel epileptic and ataxic Cacna2d2 mutant of the mouse. 
Abstract:
entla (ent) is a novel recessive phenotype of mice. The underlying mutation was mapped to chromosome 9 (60.1 centimorgans) and identified as an allele of the Cacna2d2 gene encoding the alpha2delta-2 subunit of voltage-gated calcium channels. The Cacna2d2entla allele harbors a 38-kb duplication comprising the 117 nucleotides of exon 3. The predicted duplication of 39 amino acid residues near the subunit's N terminus results in the expression of a full-length, membrane-associated protein. Western...    »
 
Journal title abbreviation:
J Biol Chem 
Year:
2004 
Journal volume:
279 
Journal issue:
Pages contribution:
7322-30 
Language:
eng 
Print-ISSN:
0021-9258 
TUM Institution:
Institut für Pharmakologie und Toxikologie