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Dokumenttyp:
journal article 
Autor(en):
Stieber, J; Herrmann, S; Feil, S; Löster, J; Feil, R; Biel, M; Hofmann, F; Ludwig, A 
Titel:
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart. 
Abstract:
Hyperpolarization-activated, cyclic nucleotide-gated cation currents, termed If or Ih, are generated by four members of the hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channel family. These currents have been proposed to contribute to several functions including pacemaker activity in heart and brain, control of resting potential, and neuronal plasticity. Transcripts of the HCN4 isoform have been found in cardiomyocytes and neurons, but the physiological role of this channel...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2003 
Band / Volume:
100 
Heft / Issue:
25 
Seitenangaben Beitrag:
15235-40 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
r Pharmakologie und Toxikologie