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Dokumenttyp:
journal article 
Autor(en):
Vaandrager, AB; Hogema, BM; Edixhoven, M; van den Burg, CM; Bot, AG; Klatt, P; Ruth, P; Hofmann, F; Van Damme, J; Vandekerckhove, J; de Jonge, HR 
Titel:
Autophosphorylation of cGMP-dependent protein kinase type II. 
Abstract:
Cyclic nucleotides are shown to stimulate the autophosphorylation of type II cGMP-dependent protein kinase (cGK) on multiple sites. Mass spectrometric based analyses, using a quadrupole time-of-flight-mass spectrometry instrument revealed that cGMP stimulated the in vitro phosphorylation of residues Ser110 and Ser114, and, at a slow rate, of Ser126 and Thr109 or Ser117, all located in the autoinhibitory region. In addition Ser445 was found to be phosphorylated in a cGMP-dependent manner, whereas...    »
 
Zeitschriftentitel:
J Biol Chem 
Jahr:
2003 
Band / Volume:
278 
Heft / Issue:
31 
Seitenangaben Beitrag:
28651-8 
Sprache:
eng 
Print-ISSN:
0021-9258 
TUM Einrichtung:
r Pharmakologie und Toxikologie