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Document type:
journal article 
Author(s):
Li, Z; Xi, X; Gu, M; Feil, R; Ye, RD; Eigenthaler, M; Hofmann, F; Du, X 
Title:
A stimulatory role for cGMP-dependent protein kinase in platelet activation. 
Abstract:
It is currently accepted that cGMP-dependent protein kinase (PKG) inhibits platelet activation. Here, we show that PKG plays an important stimulatory role in platelet activation. Expression of recombinant PKG in a reconstituted cell model enhanced von Willebrand factor (vWF)-induced activation of the platelet integrin alpha(IIb)beta(3). PKG knockout mice showed impaired platelet responses to vWF or low doses of thrombin and prolonged bleeding time. Human platelet aggregation induced by vWF or lo...    »
 
Journal title abbreviation:
Cell 
Year:
2003 
Journal volume:
112 
Journal issue:
Pages contribution:
77-86 
Language:
eng 
Print-ISSN:
0092-8674 
TUM Institution:
Institut für Pharmakologie und Toxikologie