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Dokumenttyp:
journal article 
Autor(en):
Lorenzi, PL; Reinhold, WC; Rudelius, M; Gunsior, M; Shankavaram, U; Bussey, KJ; Scherf, U; Eichler, GS; Martin, SE; Chin, K; Gray, JW; Kohn, EC; Horak, ID; Von Hoff, DD; Raffeld, M; Goldsmith, PK; Caplen, NJ; Weinstein, JN 
Titel:
Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells. 
Abstract:
L-Asparaginase (l-ASP), a bacterial enzyme used since the 1970s to treat acute lymphoblastic leukemia, selectively starves cells that cannot synthesize sufficient asparagine for their own needs. Molecular profiling of the NCI-60 cancer cell lines using five different microarray platforms showed strong negative correlations of asparagine synthetase (ASNS) expression and DNA copy number with sensitivity to l-ASP in the leukemia and ovarian cancer cell subsets. To assess whether the ovarian relatio...    »
 
Zeitschriftentitel:
Mol Cancer Ther 
Jahr:
2006 
Band / Volume:
Heft / Issue:
11 
Seitenangaben Beitrag:
2613-23 
Sprache:
eng 
Print-ISSN:
1535-7163 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie