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Dokumenttyp:
journal article 
Autor(en):
Sarbia, M; Stahl, M; von Weyhern, C; Weirich, G; Pühringer-Oppermann, F 
Titel:
The prognostic significance of genetic polymorphisms (Methylenetetrahydrofolate Reductase C677T, Methionine Synthase A2756G, Thymidilate Synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma. 
Abstract:
The present study retrospectively examined the correlation between the outcome of patients with locally advanced oesophageal squamous cell carcinoma (cT3-4 cN0-1 cM0) after multimodal treatment (radiochemotherapy+/-surgical resection), and the presence of genetic polymorphisms in genes involved in folate metabolism. In total, 68 patients who took part in a prospective multicentric trial received 5-fluorouracil (FU)-based radiochemotherapy, optionally followed by surgery. DNA was extracted from p...    »
 
Zeitschriftentitel:
Br J Cancer 
Jahr:
2006 
Band / Volume:
94 
Heft / Issue:
Seitenangaben Beitrag:
203-7 
Sprache:
eng 
Print-ISSN:
0007-0920 
TUM Einrichtung:
r Allgemeine Pathologie und pathologische Anatomie