User: Guest  Login
Document type:
journal article 
Author(s):
Quintanilla-Martinez, L; Davies-Hill, T; Fend, F; Calzada-Wack, J; Sorbara, L; Campo, E; Jaffe, ES; Raffeld, M 
Title:
Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis. 
Abstract:
p27 is a cyclin-dependent kinase inhibitor that plays a critical role in regulating G(1)/S progression, and whose activity is, in part, regulated through interactions with D-type cyclins. Mantle cell lymphoma (MCL) is characterized by the t(11; 14) translocation resulting in deregulated cyclin D1. We previously showed that p27 expression in MCL, as assessed by immunohistochemistry (IHC), does not show the usual inverse relationship to proliferate seen in most other lymphomas that do not overexpr...    »
 
Journal title abbreviation:
Blood 
Year:
2003 
Journal volume:
101 
Journal issue:
Pages contribution:
3181-7 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Institut für Allgemeine Pathologie und pathologische Anatomie