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Dokumenttyp:
journal article 
Autor(en):
Beyer, GJ; Miederer, M; Vranjes-Duri?, S; Comor, JJ; Künzi, G; Hartley, O; Senekowitsch-Schmidtke, R; Soloviev, D; Buchegger, F 
Titel:
Targeted alpha therapy in vivo: direct evidence for single cancer cell kill using 149Tb-rituximab. 
Abstract:
This study demonstrates high-efficiency sterilisation of single cancer cells in a SCID mouse model of leukaemia using rituximab, a monoclonal antibody that targets CD20, labelled with terbium-149, an alpha-emitting radionuclide. Radio-immunotherapy with 5.5 MBq labelled antibody conjugate (1.11 GBq/mg) 2 days after an intravenous graft of 5.10(6) Daudi cells resulted in tumour-free survival for>120 days in 89% of treated animals. In contrast, all control mice (no treatment or treated with 5 or 3...    »
 
Zeitschriftentitel:
Eur J Nucl Med Mol Imaging 
Jahr:
2004 
Band / Volume:
31 
Heft / Issue:
Seitenangaben Beitrag:
547-54 
Sprache:
eng 
Print-ISSN:
1619-7070 
TUM Einrichtung:
Nuklearmedizinische Klinik und Poliklinik