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Document type:
journal article 
Author(s):
Feil, R; Hartmann, J; Luo, C; Wolfsgruber, W; Schilling, K; Feil, S; Barski, JJ; Meyer, M; Konnerth, A; De Zeeuw, CI; Hofmann, F 
Title:
Impairment of LTD and cerebellar learning by Purkinje cell-specific ablation of cGMP-dependent protein kinase I. 
Abstract:
The molecular basis for cerebellar plasticity and motor learning remains controversial. Cerebellar Purkinje cells (PCs) contain a high concentration of cGMP-dependent protein kinase type I (cGKI). To investigate the function of cGKI in long-term depression (LTD) and cerebellar learning, we have generated conditional knockout mice lacking cGKI selectively in PCs. These cGKI mutants had a normal cerebellar morphology and intact synaptic calcium signaling, but strongly reduced LTD. Interestingly, n...    »
 
Journal title abbreviation:
J Cell Biol 
Year:
2003 
Journal volume:
163 
Journal issue:
Pages contribution:
295-302 
Language:
eng 
Print-ISSN:
0021-9525 
TUM Institution:
Institut für Pharmakologie und Toxikologie ; Institut für Neurowissenschaften