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Document type:
journal article 
Author(s):
Lutz, J; Yao, Y; Song, E; Antus, B; Hamar, P; Liu, S; Heemann, U 
Title:
Inhibition of matrix metalloproteinases during chronic allograft nephropathy in rats. 
Abstract:
BACKGROUND: Chronic allograft nephropathy (CAN) belongs to the major causes of long-term kidney allograft failure. One of the histologic hallmarks of CAN is interstitial fibrosis, influenced by matrix metalloproteinases (MMPs) that are controlling extracellular matrix (ECM) degradation. Whether MMPs affect the development and progression of CAN is not clear so far. To analyze the role of MMPs in CAN, we investigated the effects of an early and a late application of BAY 12-9566, an inhibitor of M...    »
 
Journal title abbreviation:
Transplantation 
Year:
2005 
Journal volume:
79 
Journal issue:
Pages contribution:
655-61 
Language:
eng 
Print-ISSN:
0041-1337 
TUM Institution:
Abteilung für Nephrologie