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Dokumenttyp:
journal article 
Autor(en):
Osterloh, P; Linkemann, K; Tenzer, S; Rammensee, HG; Radsak, MP; Busch, DH; Schild, H 
Titel:
Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses. 
Abstract:
Differences in the cleavage specificities of constitutive proteasomes and immunoproteasomes significantly affect the generation of MHC class I ligands and therefore the activation of CD8-positive T cells. Based on these findings, we investigated whether proteasomal specificity also influences CD8-positive T cells during thymic selection by peptides derived from self proteins. We find that one of the self peptides responsible for positive selection of ovalbumin-specific OT-1 T cells, which is der...    »
 
Zeitschriftentitel:
Proc Natl Acad Sci U S A 
Jahr:
2006 
Band / Volume:
103 
Heft / Issue:
13 
Seitenangaben Beitrag:
5042-7 
Sprache:
eng 
Print-ISSN:
0027-8424 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene