User: Guest  Login
Document type:
journal article 
Author(s):
Kerksiek, KM; Niedergang, F; Chavrier, P; Busch, DH; Brocker, T 
Title:
Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo. 
Abstract:
To better understand the influence of cytoskeletal regulation on dendritic cell (DC) function in vivo, the Rho guanosine triphosphatase (GTPase) Rac1 was selectively inhibited in DCs in transgenic (Tg) mice. Although transgene expression did not interfere with the migratory capacities of DC in vivo, a decreased uptake of fluorescent probes was observed. Interestingly, the absence of full Rac1 function most strongly affected the development and function of CD8+ DCs. Apoptotic cell uptake was seve...    »
 
Journal title abbreviation:
Blood 
Year:
2005 
Journal volume:
105 
Journal issue:
Pages contribution:
742-9 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene