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Dokumenttyp:
journal article 
Autor(en):
Kerksiek, KM; Niedergang, F; Chavrier, P; Busch, DH; Brocker, T 
Titel:
Selective Rac1 inhibition in dendritic cells diminishes apoptotic cell uptake and cross-presentation in vivo. 
Abstract:
To better understand the influence of cytoskeletal regulation on dendritic cell (DC) function in vivo, the Rho guanosine triphosphatase (GTPase) Rac1 was selectively inhibited in DCs in transgenic (Tg) mice. Although transgene expression did not interfere with the migratory capacities of DC in vivo, a decreased uptake of fluorescent probes was observed. Interestingly, the absence of full Rac1 function most strongly affected the development and function of CD8+ DCs. Apoptotic cell uptake was seve...    »
 
Zeitschriftentitel:
Blood 
Jahr:
2005 
Band / Volume:
105 
Heft / Issue:
Seitenangaben Beitrag:
742-9 
Sprache:
eng 
Print-ISSN:
0006-4971 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene