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Dokumenttyp:
journal article 
Autor(en):
Vossenkämper, A; Struck, D; Alvarado-Esquivel, C; Went, T; Takeda, K; Akira, S; Pfeffer, K; Alber, G; Lochner, M; Förster, I; Liesenfeld, O 
Titel:
Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control. 
Abstract:
Oral infection of C57BL/6 mice with Toxoplasma gondii results in small intestinal Th1-type immunopathology mediated by local production of IFN-gamma, TNF-alpha, and NO. To analyze whether the proinflammatory cytokines IL-12 and IL-18 play a role in the induction of immunopathology, IL-12p35/p40(-/-) and IL-18(-/-) mice were orally infected with T. gondii. Wild-type mice developed massive necrosis in their small intestines and died 7-10 days post infection. Even though IL-12p35/40(-/-) mice did n...    »
 
Zeitschriftentitel:
Eur J Immunol 
Jahr:
2004 
Band / Volume:
34 
Heft / Issue:
11 
Seitenangaben Beitrag:
3197-207 
Sprache:
eng 
Print-ISSN:
0014-2980 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene