Benutzer: Gast  Login
Dokumenttyp:
journal article 
Autor(en):
Herbert, DR; Hölscher, C; Mohrs, M; Arendse, B; Schwegmann, A; Radwanska, M; Leeto, M; Kirsch, R; Hall, P; Mossmann, H; Claussen, B; Förster, I; Brombacher, F 
Titel:
Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. 
Abstract:
Macrophage/neutrophil-specific IL-4 receptor alpha-deficient mice (LysM(Cre)IL-4Ralpha(-/flox)) were generated to understand the role of IL-4/IL-13 responsive myeloid cells during Type 2 immune responses. LysM(Cre)IL-4Ralpha(-/flox) mice developed protective immunity against Nippostrongylus brasiliensis accompanied by T(H)2 development and goblet cell hyperplasia. In contrast, LysM(Cre)IL-4Ralpha(-/flox) mice were extremely susceptible to Schistosoma mansoni infection with 100% mortality during...    »
 
Zeitschriftentitel:
Immunity 
Jahr:
2004 
Band / Volume:
20 
Heft / Issue:
Seitenangaben Beitrag:
623-35 
Sprache:
eng 
Print-ISSN:
1074-7613 
TUM Einrichtung:
r Medizinische Mikrobiologie, Immunologie und Hygiene