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Document type:
journal article 
Author(s):
Bolz, DD; Sundsbak, RS; Ma, Y; Akira, S; Kirschning, CJ; Zachary, JF; Weis, JH; Weis, JJ 
Title:
MyD88 plays a unique role in host defense but not arthritis development in Lyme disease. 
Abstract:
To assess the contribution of TLR signaling in the host response to Borrelia burgdorferi, mice deficient in the common TLR adaptor protein, myeloid differentiation factor 88 (MyD88), were infected with B. burgdorferi. MyD88-deficient mice harbored extremely high levels of B. burgdorferi in tissues when compared with wild-type littermates and greater amounts of spirochetes in tissues than TLR2-deficient mice. These findings suggest that, in addition to TLR2, other MyD88-dependent pathways play a...    »
 
Journal title abbreviation:
J Immunol 
Year:
2004 
Journal volume:
173 
Journal issue:
Pages contribution:
2003-10 
Language:
eng 
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene