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Document type:
journal article 
Author(s):
Roeder, A; Kirschning, CJ; Schaller, M; Weindl, G; Wagner, H; Korting, HC; Rupec, RA 
Title:
Induction of nuclear factor- kappa B and c-Jun/activator protein-1 via toll-like receptor 2 in macrophages by antimycotic-treated Candida albicans. 
Abstract:
We examined the role of Toll-like receptors (TLRs) by using TLR2-deficient (TLR2(-/-)), TLR4-defective (TLR4(d/d)), and double-knockout murine macrophages and human embryonic kidney (HEK) 293 cells transfected with human TLR2 or TLR4 expression plasmids after stimulation with different preparations of the human pathogenic fungus Candida albicans. Compared with wild-type macrophages, TLR2(-/-) and TLR4(d/d) macrophages had impaired recognition of viable C. albicans, whereas antimycotic (AM)-treat...    »
 
Journal title abbreviation:
J Infect Dis 
Year:
2004 
Journal volume:
190 
Journal issue:
Pages contribution:
1318-26 
Language:
eng 
Print-ISSN:
0022-1899 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene